Analysis of the glutathione S-transferase (GST) gene family
نویسندگان
چکیده
منابع مشابه
Glutathione Transferase (GST)-Activated Prodrugs
Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione. Moreover, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a ra...
متن کاملStructures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Glutathione-S-transferases (GSTs) are ubiquitous detoxification enzymes that catalyse the conjugation of electrophilic substrates to glutathione. Here, we present the crystal structures of Gtt2, a GST of Saccharomyces cerevisiae, in apo and two ligand-bound forms, at 2.23 A, 2.20 A and 2.10 A, respectively. Although Gtt2 has the overall structure of a GST, the absence of the classic catalytic e...
متن کاملAnalysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia.
The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed...
متن کاملBiochemical Study and Gene Expression of Glutathione-S- Transferase (GST) in Induced Asthma in Rat
This researchaims to stud the role of Glutathione-S-transferases in asthma under stress conditions. Also, evaluate the ability of Iraqi propolis to inhibit the free radicals production in asthmatic rats too.GST enzyme was partially purified from rats liver after induction asthma. The experimental Sprague-Dawly rats were divided into four groups. (G1) control group, (G2) asthma group, (G3) asthm...
متن کاملGlutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore.
Cigarette smoking is a risk factor for colorectal cancer. Putative colorectal procarcinogens in tobacco smoke include polycyclic aromatic hydrocarbons and heterocyclic aromatic amines that are known substrates of glutathione S-transferases (GSTs). This study examined the influence of functional GST gene polymorphisms on the smoking-colorectal cancer association in a population known to be minim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Genomics
سال: 2004
ISSN: 1479-7364
DOI: 10.1186/1479-7364-1-6-460